Gene expression patterns associated with tumor-infiltrating CD4+ and CD8+ T cells in invasive breast carcinomas

Breast carcinoma is one of the most common tumors in women. The immune microenvironment, especially T cell infiltration, related to occurrence and prognosis breast carcinoma. This study investigated gene expression patterns associated with tumor-infiltrating CD4+ CD8+ cells invasive carcinomas. data corresponding clinical phenotype from Cancer Genome Atlas Invasive Carcinoma (TCGA-BRCA) were downloaded. stromal score calculated using ESTIMATE. differentially expressed genes (DEGs) a high vs. low screened then functionally enriched. Cibersort algorithm, cell-related identified Spearman correlation test infiltrating abundance DEGs. Moreover, miRNA-mRNA pairs lncRNA-miRNA predicted construct competing endogenous RNAs (ceRNA) network. Kaplan-Meier (K-M) survival curves also plotted. In total, 478 DEGs 796 identified. addition, 39 78 identified; these, 14 significantly BRCA patients. for genes, chr22-38_28785274-29006793.1–miR-34a/c-5p–CAPN6 axis was ceRNA network, whereas chr22-38_28785274-29006793.1–miR-494-3p–SLC9A7 genes. might regulate cellular activities respectively, BRCA.